Cardiovascular Functional Genomics Laboratory
Mission: Our facility is available to all researchers with funding from the National Heart, Lung, and Blood Institute and those involved in Cardiovascular Research. We provide expertise in the use of microarrays for genomics studies, and offer a comprehensive and integrated approach to array analysis.
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Facility Personnel:
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Services OfferedWe offer the following services. Click the name of the service in the table below to learn more.
EquipmentClick the name of the equipment in the table below to learn more.
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Welcome to the CCBC Cardiovascular Functional Genomics Laboratory! The laboratory was established in 2003 by Dr. Cam Patterson, and facilitates the use of microarray technology for the cardiovascular research community at UNC. Our facility is available to all researchers with funding from the National Heart, Lung, and Blood Institute and those who are doing Cardiovascular Research. We provide expertise in the use of arrays for genomics studies and offer a comprehensive and integrated approach to array analysis. We are a multidisciplinary group that interact closely with investigators, offering support for all phases of each study; including experimental design, sample preparation, hybridization, quality control, data analysis, and database maintenance. The core provides services using the Agilent 60mer ink-jet platform, in both one and two color formats. These arrays are available for a wide variety species platforms and applications, and are easily customizable at no additional cost. If you require
help preparing a project or a grant application that involves
microarray experiments, or if you have general questions about the
services we offer, please contact: Peter C. Charles, PhD (email: pcharles(at)med.unc.edu, phone: 919-843-1610) CFGL Publications
Charles PC, Alder BD, Hilliard EG, Schisler JC, Lineberger RE, Parker JS, Mapara S, Wu SS, Portbury A, Patterson C, and GA Stouffer. Tobacco use induces anti-apoptotic, proliferative patterns of gene expression in circulating leukocytes of Caucasian males. 2008. BMC Medical Genomics.1:38. Wu Y, Ferguson JE 3rd, Wang H, Kelley R, Ren R, McDonough H, Meeker J, Charles PC, Wang H, and C Patterson. PRDM6 is enriched in vascular precursors during development and inhibits endothelial cell proliferation, survival, and differentiation. 2008. J Mol Cell Cardiol. 44:47-58. Charles PC, Mapara S, Parker JS, Herrmann RA, and C Patterson. Gene expression profiling in rat smooth muscle cells reveals novel regulatory pathways modulated by rapamycin and paclitaxel. 2007. The Internet Journal of Genomics and Proteomics. 2007. 3:1. Ferguson JE 3rd, Wu Y, Smith K, Charles PC, Powers K, Wang H, and C Patterson. Ankyrin Repeat and SOCS Box Protein 4 (ASB4) is a Hydroxylation Substrate of Factor Inhibiting HIF1{alpha} (FIH) and Promotes Vascular Differentiation via an Oxygen-Dependent Mechanism. 2007. Mol Cell Biol. 18:6407-19. Ren R, Charles PC, Zhang C, Wu Y, Wang H, and C Patterson. Gene expression profiles identify a role for cyclooxygenase 2-dependent prostanoid generation in BMP6-induced angiogenic responses. 2007. Blood.; 109:2847-53. Wang H, Charles PC, Wu Y, Ren R, Pi X, Moser M, Barshishat-Kupper M, Rubin JS, Perou C, Bautch V, and C Patterson. Gene expression profile signatures indicate a role for Wnt signaling in endothelial commitment from embryonic stem cells. 2006. Circ Res. 98:1331-9. He XR, Zhang C, and C Patterson. Universal mouse reference RNA derived from neonatal mice. 2004. Biotechniques. 3:464-8. Collaborators
Chuck Perou, PhD Genetics Terry Magnuson, PhD Genetics Patricia Chang, MD Medicine Morgan Giddings, PhD Microbiology and Immunology Rick Stouffer, MD Medicine Craig Selzman, MD Surgery Janet Rubin, MD Medicine Nancy Demore, MD Surgery Julius Aitsebamo, MD Medicine Monte Willis, PhD/MD Pathology Craig Lee, PharmD/PhD Pharmacy Wei Wang, PhD Computer Science Leonard McMillan, PhD Computer Science CFGL Alumni
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