The Patterson laboratory uses molecular, genetic, and physiologic approaches to ask questions regarding events that underlie the processes of angiogenesis, vascular development, cardiac failure, and atherosclerosis. Our laboratory employs a wide range of methods, including standard molecular techniques, gene discovery applications, genetically modified animals, and microphysiologic techniques. We have a particular interest in understanding the genes that regulate angiogenesis, identifying stress-responsive genes that modify cardiac function, and characterizing oxidative pathways in atherogenesis.